STRUCTURAL HETEROGENEITY OF THE ENDOCRINE PANCREATIC ISLETS PART 1. MORPHOLOGICAL DIFFERENCES BETWEEN HUMAN AND OTHER SPECIES ISLETS
Abstract
Histological studies of human pancreatic islets and those of laboratory animals tend to emphasize, that they display more differences than similarities. Variability in islets architecture and cell composition has been revealed between different species as well as within the same species. Human pancreatic islets are more heterogeneous than those in other species. Most of human islets do not have the core-mantle segregation of endocrine cells and B- cells are intermingled with other cell types. Human islets have relatively fewer B-cells and more A-cells as compared to rodent and other species islets, as well as more intra-islet variations of these cells. The density of islets and the number of large islets in the region of the human pancreatic tail is significantly higher than in the region of the head and body, which reflects regional heterogeneity. Moreover, islets in the uncinate process of the pancreas have predominantly PP-expressing cells.
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