EFFECT OF MELATONIN ON THE MORPHOLOGY OF MITOCHONDRIA AND OTHER CELLULAR COMPONENTS OF THE HEPATOCYTE
Abstract
Background. Melatonin (N-acetyl-5-methoxy-tryptamine) is an endogenous indoleamine, which is synthesized mainly by the pineal gland and has a pronounced antioxidant effect. Objective. To study the features of the ultrastructure of the liver exposed to melatonin.
Materials and methods. Melatonin was administered to nonlinear male rats intragastrically at a dose of 3 mg / kg /day for 14 days. An electron microscopic study of liver samples with mitochondrial morphometry was performed.
Results. Melatonin affects the ultrastructural components of hepatocytes, including changes in the mitochondrial dynamics towards reducing the size and branching of the organelles and increasing their numbers while maintaining the concentration of mitochondrial inner membranes in the cell.
Conclusion. Melatonin optimizes the ultrastructure of rat hepatocytes while preserving the morphological state of the microvascular bed and organ biliary system.
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