FREE AMINO ACIDS OF LIVER AFTER INTRAGASTRIC ADMINISTRATION OF INFEZOL40 TO ANIMALS
Abstract
Background. Widespread use of amino acid supplements in preventive and sports medicine, their appointment in liver diseases, treatment of insulin resistance and obesity, suggest their enteral administration.
The aim of the study was to analyze the concentrations of free amino acids in the liver tissue of rats in dynamics after intragastric administration of Infezol40.
Materials and methods. The experiment was carried out on rats weighing 120-140 g, which were administered intragastrically at a dose Infezol40 solution 20 ml / kg body weight, decapitation was performed over 10 min, 20 min, 30 min or 45 min, respectively. Determination of free amino acids in liver tissue was performed by reversed-phase HPLC.
Results and discussion. Intragastric administration of Infezol40 for 45 minutes does not change the total amount of proteinogenic amino acids in liver tissue, however, against this background, the level of arginine increased statistically and the arginine/citrulline ratio increased.
Conclusions. Thus, the amino acids entering the cells of the small intestine significantly affect the metabolism of these cells, which modulates the number and range of amino acids reaching the liver. In turn, their transformation in the liver should have an effect on the amino acid pool of the blood plasma.
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