CLINICAL VALUE OF PERIPHERAL MICROCIRCULATION DISORDERS IN DIFFUSE LIVER DISEASES
Abstract
Background. At present the involvement of the microcirculatory level in the development of pathological processes in the liver is actively being discussed.
Objective – to investigate the state of the microcirculation in various forms of diffused liver diseases by noninvasive laser Doppler imaging (LDI).
Materials and methods. The study included 137 patients with diffuse liver disease: 30 patients with non-alcoholic fatty liver disease (NAFLD), 33 patients with alcoholic steatohepatitis (ASH), 34 patients with viral hepatitis (HVH), 40 patients with liver cirrhosis. The evaluation of the peripheral microcirculation was performed using methods of noninvasive laser Doppler, by registration of blood flow parameters: perfusion (c.u) concentration (c.u) speed (mm/s) in the area of thenar and hypothenar. To estimate the severity of liver fibrosis in patients of the main group transient elastography was performed.
Results. In all study groups changes in blood flow values in comparison with the control group were observed. But the most significant disturbances in the parameters of peripheral microcirculation were detected in patients with liver cirrhosis. This fact indicates a more significant damage to the hepatic tissue in this pathological process, the restructuring of the hepatic blood flow and possible changes in vasodilator and vasoconstrictor neurotransmitters.
Conclusion. The correlation between the degree of liver tissue damage and the level of microcirculatory disorders was revealed.
References
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